Trans-omic profiling uncovers molecular controls of early human cerebral organoid formation Carissa Chen, Scott Lee, Katherine G. Zyner, Milan Fernando, Victoria Nemeruck, Emilie Wong, Lee L. Marshall, Jesse R. Wark, Nader Aryamanesh, Patrick P.L. Tam, Mark E. Graham, Anai Gonzalez-Cordero, and Pengyi Yang VOLUME 43, ISSUE 5, 114219, MAY 28, 2024; https://doi.org/10.1016/j.celr...
Bioelectric potential in next-generation organoids: electrical stimulation to enhance 3D structures of the Central Nervous System. Michelle O’Hara-Wright, Sahba Mobini, Anai Gonzalez-Cordero. Frontiers in Cell and Developmental Biology. 17 May 2022; doi.org/10.3389/fcell.2022.901652.
Antioxidant and lipid supplementation improve the development of photoreceptor outer segments in pluripotent stem cell-derived retinal organoids. West EL, Majunder P, Naeem A, Fernando M, O'Hara-Wright M, Lanning E, Kloc M, Ribeiro J, Ovando-Roche P, Shum IO, Jumbu N, Sampson R, Hayes M, Bainbridge JWB, Georgiadis A, Smith AJ, Gonzalez-Cordero A, Ali RR. 2022, Stem Cell Reports. 2022 Mar 15:S2213-6711(22)00132-1. doi: 10.1016/j.stemcr.2022.02.019.
Human iPSC-Derived Retinal Organoids and Retinal Pigment Epithelium for Novel Intronic RPGR Variant Assessment for Therapy Suitability. Chahine Karam F, Loi TH, Ma A, Nash BM, Grigg JR, Parekh D, Riley LG, Farnsworth E, Bennetts B, Gonzalez-Cordero A, Jamieson RV. 2022, J Pers Med. 2022 Mar 21;12(3):502. doi: 10.3390/jpm12030502.
AAV-p40 bioengineering platform for variant selection based on transgene expression. Westhaus A, Cabanes Creus M, Jonker T, Sallard E, Navarro RG, Zhu E, Baltazar G, Lee S, Wilmott P, Gonzalez-Cordero A, Santilli G, Thrasher AJ, Alexander IE, Lisowski L. 2022, Hum Gene Ther. 2022 Mar 17. doi: 10.1089/hum.2021.278.
Evaluation for Retinal Therapy for RPE65 Variation Assessed in hiPSC Retinal Pigment Epithelial Cells. Nash BM, Loi TH, Fernando M, Sabri A, Robinson J, Cheng A, Eamegdool SS, Farnsworth E, Bennetts B, Grigg JR, Chung SK, Gonzalez-Cordero A, Jamieson RV. 2021, Stem Cells International. 2021:4536382. DOI: 10.1155/2021/4536382.
Nash BM, Loi TH, Fernando M, Sabri A, Robinson J, Cheng A, Eamegdool SS, Farnsworth E, Bennetts B, Grigg JR, Chung SK, Gonzalez-Cordero A, Jamieson RV. 2021 Evaluation for Retinal Therapy for RPE65 Variation Assessed in hiPSC Retinal Pigment Epithelial Cells. Stem Cells Int. Dec 13;2021:4536382.
Ribeiro et al., Gonzalez-Cordero, & Ali. 2021. Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors. Cell reports, 35(3), 109022. 10.1016/j.celrep.2021.109022
Gonzalez-Cordero et al., 2018. Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells. Human Gene Therapy. 10.1089/hum.2018.027
Gonzalez-Cordero et al., 2017. Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors. Stem Cell Reports, 9 (3): 820–37. 10.1016/j.stemcr.2017.07.022
Pearson; Gonzalez-Cordero et al., 2016. Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors. Nature Communications, 7,13029. 10.1038/ncomms13029
Gonzalez-Cordero et al., 2013. Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nature Biotechnology, 31: 741–747. 10.1038/nbt.2643
"Research saved my baby's life"
At just two weeks old, Alessia was diagnosed with Spinal Muscular Atrophy. Thanks to ground-breaking gene therapy, Alessia became the first child in Australia to receive life-saving treatment, giving her a future her parents thought they might never see.